This game was released before the second Yu-Gi-Oh series was televised, but includes many of its characters. For reference, this game was released December 9th 1999 in Japan. All dates are from their Japanese release, as this is where they originate.

•Pegasus appeared in the first episode of the second series, April 18th, 2000.
•Rex and Weevil appeared in the 2nd episode, April 25th, 2000.
•Mai Valentine appeared in the 3rd, May 5th 2000.
•Bandit Keith appeared in the anime in the 16th episode, August 8th 2000.
•Ishizu Ishtar, Priest Seto, and Pharaoh Atem (whom the player controls) all appeared in episode 52, April 24th 2001.
•Shimon Muran (Simon in the game) would make his first appearance in episode 201 on April 21st 2004.