There are a number of references to the Star Trek series in the game;

• A Goblin Doctor known as "Doc" found in Area 52 will say "Damnit Boots, I'm a doctor not a priest!" after turning in the quest "That Little Extra Kick." This is in reference to Dr. McCoy from Star Trek :The Original Series.
• Also in Area 52 are several Goblin NPCs working on a rocket, all wearing Gold Shirts and Black pants, in reference to the Engineering crews of Star Trek: The Next Generation. Chief Engineer "Trep" is in reference to Chief Engineer Charles "Trip" Tucker from Star Trek: Enterprise. "Trep" also has a quest named "Report to Engineering" in which the player must deliver Etherlithium Matrix Crystals to him, referencing the Dilithium Matrix Crystals which regulates the anti-matter flow for the ships in the Star Trek series.
• In the Exodar Holographic Emitters, there are five NPCs by the names of Curzon, Tobin, Torias, Emony, and Audrid. All five of these are in reference to Dax's previous hosts from Star Trek: Deep Space Nine.
• The camp "Bash'ir Landing" may be another reference to Star Trek: Deep Space Nine, namely to Julian Bashir the Chief Medical Officer of Deep Space Nine.
• Warden Treelos, a lone-surviving Druid near Cenarion Thicket will randomly yell "There are four lights!" This is a reference to Captain Picard from Star Trek: The Next Generation, specifically from the two-part episode Chain of Command.
• In Gadgetzan, there is a Gnome Engineer wearing a gold shirt and black pants with the name "Jhordy Lapforge", in reference to Geordi La Forge from Star Trek:The Next Generation.
• Another gold-and-black Gnome Engineer can be found in Blade's Edge Mountains by the name of Smiles O'Byron, in reference to Chief Miles "Smiley" O'Brien from both Star Trek:The Next Generation and Star Trek:Deep Space Nine. The NPC even specializes in Transporters, much like the Star Trek equivalent did.
• In Stormwind City, there is an NPC by the name of Lenny "Fingers" McCoy, in reference to Dr. Leonard "Bones" McCoy from Star Trek:The Original Series.
• Nogg's Machine Shop found in Orgrimmar is named after the Engineer-savant Ferengi called Nogg, from Star Trek: Deep Space Nine.
• Two Goblins named Scooty and Sprock are in reference to Montgomery "Scotty" Scott and Spock both from Star Trek: The Original Series. Scooty in particular wears a white shirt and black vest, much like what Scotty wore in his later years.