In a 1999 interview with the magazine "Used Games", then HAL Laboratory president Satoru Iwata said that, because of his pride with how well it replicated a pinball machine, the basic engine used for the 1984 NES game Pinball was later repurposed for the 1999 Game Boy title Pokémon Pinball. It is unknown if the latter game's sequel, Pokémon Pinball: Ruby & Sapphire, also uses this engine.

The Catch 'Em Mode music in Blue Field is based on the music from the Japanese opening of the Pokémon Anime.

Mew can appear as a catchable Pokémon in Indigo Plateau once the player has completed the Mewtwo bonus stage twice (it then has a 1/16 chance of being encountered when all three GET lights are lit). However, it can't actually be caught by normal means, because a special routine increments a counter in a RAM address whenever Mew is hit, and each of the 4 steps in the "catch!" sequence requires the player to hit Mew 256 times (for a total of 1024 hits, basically impossible within a two minute timeframe). Mew's Pokédex entry will be unlocked when it is encountered instead of when it is obtained.