The development for Kid Icarus: Uprising began with a vague concept of a game conceived by Masahiro Sakurai that would switch between aerial and land combat. At the recommendation of then-Nintendo president Satoru Iwata, it was decided to incorporate a pre-existing Nintendo IP onto the concept, and Sakurai would ultimately land on Kid Icarus, as he was aware of its endearing popularity in the west and a desire from fans for a new installment, especially with its protagonist, Pit, being included as a playable fighter in Super Smash Bros. Brawl.

Another IP that was briefly considered was the Star Fox franchise. However, Sakurai ultimately felt that the character of Pit and his universe were more flexible and fitting for the type of game he was creating with Uprising.