Two unused sprites in the SNES version of the game are demonic parodies of Mickey Mouse and Donald Duck, likely intended for the Tokyo Destinyland theme park, based on the real-life Tokyo Disneyland park.

In the PC Engine release of the game, two much less similar-looking parodies of the characters appear in Tokyo Destinyland as NPCs under the names "Zombie Mouse" and "Demon Duck", possibly as a workaround to copyright issues with The Walt Disney Company due to parodies not falling under fair use in Japanese copyright law.

On April 24, 1994, the dismembered remains of a body was found all over Japan's Inokashira Park. The murder was almost identical to the beginning of Shin Megami Tensei, released two years earlier. The main character dreams of a murder by dismemberment in Inokashira Park, only to wake up and find the dream came true. It is believed that the murderer was mimicking the events of the game, but was never proven and the case remains unsolved to this day.