Most of Pokemon Gold and Silver's music was created on an Amiga computer, converted to MIDI, and then reconverted to the game's music format. Some songs, though, like the Unown radio music, were created by hand directly in the GSC music format.

A recurring oddity in the Pokémon games is that the Gym Leader and later Elite Four member Koga, the Kanto Region's Poison-type expert, threatens to defeat his opponents with both Poison and Sleep tactics. In Red and Blue, he states:


In Gold, Silver, Crystal, and their remakes HeartGold and SoulSilver, he states:


In FireRed and LeafGreen, he states:


Despite this, the only game in the series where Koga's main team uses any Sleep-inducing moves is Yellow, where two of his Venonats have Sleep Powder. In contrast, all of Koga's teams have incorporated Poisoning moves, with some of his teams being entirely composed of Pokémon using such moves. Although possibly a mistake, this might also tie into the theme of misdirection, which would be fitting for the ninja-themed Fuchsia Gym.