While most of the memes featured in Meme Run are well-known mainstream memes that were already quite storied by the time of the game's release, one meme included in the game is much more obscure - that being "Bigley", a mosquito-like parody of Ridley from the Metroid series meant to mock fierce fandom debates over whether the latter character was "too big" to feasibly include in the Super Smash Bros. franchise. This character was hugely popular within the Miiverse community, and was often considered a mascot for the community during its heyday, however, Meme Run and its sequel Bigley's Revenge were the only footprint Bigley managed to impart outside of the Miiverse community, with the meme being so obscure that its article was rejected from Know Your Meme.