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For an interaction during one of the puzzles in Chapter 1, it is shown that Sherlock Holmes is allergic to sheep dander. However, in Chapter 9, when Spoiler:everyone including the main characters turn into Dr. Watson, there's an easily missable interaction with the sheep, where if you throw its dander onto the detective, he won't react at all. The characters acknowledge this with the following dialogue:
Watson: "You're not sneezing, Sherlock?"
Sherlock: "Indeed. Spoiler:It would seem that inhabiting your body has its good point. Good point, singular."
Sherlock: "Indeed. Spoiler:It would seem that inhabiting your body has its good point. Good point, singular."
Sherlock's reaction in Chapter 1:
https://www.youtube.com/watch?v=zULzwp0TsYk&t=770
Sherlock's reaction in Chapter 9:
https://www.youtube.com/watch?v=S_i8vZi6GV4
https://www.youtube.com/watch?v=zULzwp0TsYk&t=770
Sherlock's reaction in Chapter 9:
https://www.youtube.com/watch?v=S_i8vZi6GV4
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