In New Reno, there is a Boxing Arena in which the player can participate in Boxing matches. Two NPCs that the player can fight, Evan Holyfeld and Mike "The Masticator", reference the infamous boxing match between Evander Holyfield and Mike Tyson in which Mike Tyson bit and tore a chunk of Holyfield's ear.

Evan Holyfeld's dialogue alludes to this as well, and if the player fights and loses to Mike "The Masticator", there is a chance the player will be holding a unique item - their own ear, alongside with a permanent -1 to their Charisma stat.