The Saturn version of the game also added a second Tyrant. After the player's first victory over the Tyrant that Wesker unleashes, when attempting to leave, another Tyrant will burst out of its stasis container.
A zombified Albert Wesker can be found in the Battle Game minigame, exclusive to the Saturn port. He is far more durable than other zombie enemies found in the game.
In the Sega Saturn version of Resident Evil, the Hunter Alpha's of the original game were replaced by a variant called Tick, which was a somewhat insectoid looking Hunter with its sickle arms and antennae.