The game contains multiple references to previous games in the series. Most notably when Claire tells Moira a gun is "more reliable than any person" (quoting Steve from Code: Veronica), Barry saying he is the master of unlocking (referencing a scene from the original game) and Claire saying she was almost "a Claire sandwich" (referencing Barry from the first game). Also worth noting is that just like in her previous appearance, Claire wakes up abducted on a prison island overrun by zombies and other creatures.

At one point the developers considered giving Natalia alternate ways of attacking, one of them being an ability to shoot lasers out of her fingers. The idea was even implemented in the game for a time during development but was removed because it felt "too super hero".

A girl featured in the concept art of a pitch by Creative Assembly for a new Resident Evil game bears a striking resemblance to Natalia Korda from Resident Evil: Revelations 2. The images, by Brad Wright, depict a girl on a hospital bed and show her having some kind of unnatural powers. These story elements were all later included in Resident Evil: Revelations 2. Wright put the images online in 2015 a few months after the release of the game, though his statements imply that the pitch was made years before then.