During the "Tali: Treason" Loyalty Mission, Shepard is introduced to Admiral Zaal'Koris vas Qwib-Qwib, with the "vas Qwib-Qwib" part referring to the ship he lives in following his Pilgrimage away from the fleet. If Shepard further questions Zaal'Koris about the Qwib-Qwib and why he has not changed its name to something less embarrassing, he comments about possible alternative names like "the Defrahnz" or "the Iktomi". Spoiler:Putting those names next to the "vas" title creates the names "vas Defrahnz" and "vas Iktomi", referencing the vas deferens and the related term vasectomy respectively.

The Qwib-Qwib ship itself may also be a direct reference to the ship of the same name from Fred Saberhagen's science-fiction novel series Berserker.