According to the game's director and producer Hiroshi Yoshimura in YouTuber Paolo fromTOKYO's "Day in the Life of a Japanese Game Programmer" video, it took the development team of 200 people up to five years to make the game after they first planned it. He also revealed in the video that they would continue to update Code Vein by listening to user feedback as well as making new downloadable content.

In a pre-release gameplay video from 2018, at the end of a tour of the Home Base, a lit sign featuring the logo for the pizza restaurant chain Domino's can be seen hanging on a wall near the refrigerator. This sign would be removed in the final game, but within the game's files are several voice lines spoken by the game's main cast (Coco, Davis, Eva, Io, Jack, Louis, Mia, Rin and Yakumo) talking about eating freshly delivered pizza in an unusually glorifying manner without mentioning the company by name. It's unclear how these voice clips would have been used in the game, but when taken with the unused Domino's sign, it's believed that this was all part of a planned promotional tie-in that fell through when the game was delayed to 2019, where Domino's would have somehow survived the apocalypse in the game's story and adapted to the Revenants and the Lost.