Event 44: Mewtwo Strikes! is a reference to the first Pokemon movie, the main feature of which was titled "Mewtwo Strikes Back."

In the event the main objective is to K.O. Mewtwo without K.O.'ing Zelda, Mewtwo only appears 15 seconds into the battle.
Zelda also has a darker appearance in the event, which references how Nurse Joy, still under control by Mewtwo, disguises herself as the mystery woman in the movie.
Contributed by JelloBoyInc