There's a disease in-game called "Ticklebritch" that typically goes unused in normal gameplay, but the DLC Mehrune's Razor provides a singular way to contract it. If the player picks up a certain hoe in Sundercliff Mines, they will contract the disease. Given that the only way to contract this disease is through picking up a hoe, this is likely a joke by developers alluding to STDs.
Contributed by ClaudX